John M Routes, MD

Allergy Immunology, Internal Medicine
Children’s Wisconsin since 2006
  • Medical director, Allergy/Clinical Immunology, Children's Wisconsin
  • Professor and chief, the Medical College of Wisconsin

Accepting new patients



Dr. John Routes serves as the co-Director of the Clinical and Translational Science Institute of Southeast Wisconsin and the Director of the Jeffrey Model Foundation (JMF) Research and Diagnostic Center for Primary Immunodeficiencies at the Medical College of Wisconsin. Dr. Routes received his undergraduate degree at Indiana University, Bloomington (Phi Beta Kappa), Medical Degree at Indiana University School of Medicine, Indianapolis (Alpha Omega Alpha), his training in Internal Medicine at the University of Utah and Fellowship training in Allergy and Clinical Immunology and Infectious Diseases at the University of Colorado and National Jewish Health, where he was a faculty member until 2006 when he assumed his present position at the Medical College. Dr. Routes has served on numerous NIH study sections, including Chairman of the “Opportunities for Collaborative Research at the NIH Clinical Center” study section and is currently a member of the “Investigations in Primary Immunodeficiency” study section and is a voting member of the FDA Immunology Devices and Medical Devices Panels. In 2008, Dr. Routes was the Principal Investigator for the pilot study in Wisconsin that instituted the first statewide newborn screening program for severe combined immunodeficiency. In addition to a research interest in developing high-throughput screening assays adaptable for population-based newborn screening for primary immunodeficiencies, Dr. Routes has a longstanding interest in defining the etiology and optimizing the treatment of the granulomatous and lymphocytic interstitial lung (GLILD), a major complication in patients with common variable immunodeficiency (CVID). 


  • Allergy Immunology, Internal Medicine

Areas of Interest

  • Pediatrics
  • Allergy immunology
  • Immunodeficiency
  • Severe combined immune deficiency SCID
  • Sinusitis
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Education and Awards


  • 1981, Indiana University School of Medicine, MD


  • 1984, University of Utah (Salt Lake City, UT) - Internal Medicine


  • 1990, University of Colorado (Denver, CO) - Infectious Disease
  • 1989, University of Colorado School of Medicine - ALLERGY AND IMMUNOLOGY


  • Best Doctors in America
  • Health Care Hero Award, Milwaukee Small Business Times
  • Immune Deficiency Foundation, LeBien Visiting Professor
  • Pioneer in Newborn Screening-Dream Maker Award, Jeffrey Modell Foundation 
  • U.S. News & World Report, Top Doctors 
  • President, Clinical Immunology Society
  • Milwaukee Magazine Top Doctors

Research and publications


Ratings and Reviews

Question rating breakdown