Desmopressin Stimate nose spray (1309)

Key points below

ALERT: CALL 9-1-1 if your child has trouble breathing.

 How does IN DDAVP work?

Intranasal desmopressin, or IN DDAVP, is a medicine that helps stop bleeding in patients with von Willebrand disease, platelet function defects, and mild hemophilia A. These bleeding problems are caused by low amounts of clotting proteins in the blood or because platelets don’t work well. IN DDAVP helps release more proteins and helps platelets stick together. Then a blood clot can form and bleeding will stop.

The medicine starts to work about 30 minutes after it is given.  It has the greatest effect in 1 to 3 hours. The effect may last 8 to 12 hours or longer.
Patients with heart problems or a history of blood clots should not use IN DDAVP. 

What do I need to know about this medicine? 

How do I give IN DDAVP?

1. Check the label and expiration date before giving each dose. Do not give expired medicine.
2. If possible, children should blow their nose to clear out any mucus before getting IN DDAVP.
3. Tilt the bottle so the tube inside the bottle is in the medicine.
4. Before using the medicine for the first time, prime it by pumping it into the air. Do this about 3 or 4 times.  Point bottle away from face when priming. 
5. Give the correct number of sprays. If your child’s dose is more than one spray, give one spray into each nostril. 
6. Tell your child to sniff in as the medicine is sprayed into the nose.
7. Rinse the spray tip with hot water and dry with a clean cloth or tissue.
8. Be sure to write down how much you used on the log sheet that comes in the box.

Remember fluids must be limited for 24 hours after use.  

What are the side effects?


Less often


What else do I need to know?


Call your child’s doctor, nurse, or clinic if you have any concerns or if your child has:

  • Faster than normal heart rate.
  • Rapid weight gain or swelling.
  • Any bleeding that won’t stop.
  • Soreness or bleeding in the nose.
  • Dizziness.
  • Confusion.
  • Seizures.
  • Vision changes.
  • Headaches or other pain not helped by acetaminophen (Tylenol®).
  • Signs of allergic reaction such as hives, wheezing, throat swelling, fever or chills.
  • Special health care needs not covered by this information.