Tobramycin: High dose for inhalation (1873)

Key points below

 (TOBI® and other approved generics)

Tobramycin (TOBI) is a medicine used to treat chronic lung infections.  It comes as a liquid that is made into a mist. This is called nebulized. Your child breathes in (inhales) the mist during a treatment.      

Your child’s doctor or nurse will explain how and when to give this medicine to your child.  

Possible side effects

Tell the doctor, nurse, or pharmacist if your child has these or any other side effects:

Supplies needed

Home Nebulizer machine, called a compressor. 
Only use the Pari LC® Plus nebulizer to give TOBI and other approved generics.
Tobramycin inhalation solution 300 mg.
Steps to follow
1.   Wash your hands.
2.  Take the cover off the nebulizer cup.
3.  Twist and remove the smaller end of the ampule.
4.  Squirt all of the medicine into the nebulizer cup.  Do not dilute with saline solution.  Put the cover on the nebulizer cup.
5. Start the treatment.  It should last 10 to 15 minutes.
6. If the treatment takes longer than 10 to 15 minutes, you may need to replace:
Your Pari LC Plus nebulizer
The compressor 
The compressor filter 

If your child is taking more than one medicine

Take them in this order:
           _____ Short-acting Bronchodilator (Albuterol or Xopenex®)
+Pulmicort Respules® or Intal® may be mixed with Albuterol and be given together
_____ Anticholinergic (Atrovent®, Combivent ® or Duoneb®)
_____ Hypertonic Saline
_____ DNase (Pulmozyme®)
_____ Bronchial hygiene / Airway Clearance
_____ Long-acting Bronchodilator
_____ Antibiotic
_____ Inhaled Steroid

Special information

Do not let anyone else take this medicine.
General information about TOBI or generic medicine:
Never use a nebulizer with a clogged nozzle.  If the nozzle is clogged, no mist will come out.  It will need to be replaced.  Clean the Pari LC right away after nebulizer treatment.  This will help keep it from getting clogged.
To replace the compressor, call your Durable Medical Equipment supplier or the CF Center at (414) 266-6730.
Do not mix this medicine with other medicines.  You may use the same Pari LC nebulizer as you use for the bronchodilator medicine.   Rinse the nebulizer well with sterile water before adding the medicine.  If you do not rinse the nebulizer, this medicine may foam.

Storage, refills and when to throw away the TOBI or generic medicine:

Keep this medicine out of the reach of children.
Store this medicine in the refrigerator.  If a refrigerator is not available, store the foil pouches at room temperature for up to 28 days.  Un-refrigerated medicine may darken in color.  It is normally slightly yellow.  The color change does not change the quality. 

You should not use TOBI or generic:

If there are particles in the solution.
If it has been stored at room temperature for more than 28 days.
If it looks cloudy.
After the expiration date.


Call your child’s doctor, nurse, or clinic if you have any questions or concerns or if your child has:

  • Any side effects.
  • Special health care needs that were not covered by this information.