Jeffrey L Segar, MD

• Milwaukee Campus-Children's Wisconsin
  8915 W. Connell Court
  Milwaukee, WI 53226

Services

• Neonatology

Dr. Segar has an established record of basic, clinical and translational research focused on developmental cardiovascular, renal and metabolic physiology. For over 20 years Dr. Segar utilized a fetal and newborn sheep model to study the functional role of the autonomic nervous system in early life as well as cardiac adaptation to pressure and volume load. Over the past half decade, Dr. Segar has focused his work on the role of early life sodium deficiency on growth, metabolism and neurobehavior. His clinical work has established that many preterm infants experience sodium deficiency which impairs optimal somatic growth. He has published a number of research articles and reviews regarding early life renal function and physiological approaches to fluid and electrolyte management in NICU patients. His current basic research work, which is funded by the Children’s Research Institute and the NIH utilizes mouse models of early life sodium depletion to examine the molecular mechanisms by which sodium impacts growth, energy expenditure, sympathetic nervous system activity, neurobehavior and cardiovascular function.

Areas of Interest

• Neonatology

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Education

• 1986, University of Wisconsin School of Medicine and Public Health, MD

Residencies

• 1989, University of Iowa Hospitals and Clinics - Pediatrics

Fellowships

• 1992, University of Iowa Hospitals and Clinics - Neonatal-Perinatal Medicine

Research

• Fetal hyperglycemia acutely induces persistent insulin resistance in skeletal muscle. (Kua KL, Hu S, Wang C, Yao J, Dang D, Sawatzke AB, Segar JL, Wang K, Norris AW) JEndocrinol 2018 Nov 01 PMID: 30444716 PMCID: PMC6494731 11/18/2018  PlumX Metrics  

• Physiological Approach to Sodium Supplementation in Preterm Infants. (Segar DE, Segar EK, Harshman LA, Dagle JM, Carlson SJ, Segar JL) Am J Perinatol 2018 Aug;35(10):994-1000 PMID: 29486497 PMCID: PMC6059989 02/28/2018  PlumX Metrics  Article has an altmetric score of 9

• Causes and circumstances of death in a neonatal unit over 20 years. (Michel MC, Colaizy TT, Klein JM, Segar JL, Bell EF) Pediatr Res 2018 04;83(4):829-833 PMID: 29443114 PMCID: PMC5935571 02/15/2018  PlumX Metrics  Article has an altmetric score of 2    2 Citations

• Impact of the ovarian cycle and pregnancy on plasma chemistry values in ewes. (Zywicki ME, Blohowiak SE, Magness RR, Segar JL, Kling PJ) J Vet Diagn Invest 2018 Mar;30(2):238-244 PMID: 29291683 PMCID: PMC5810928 01/03/2018  PlumX Metrics  

• Ovine uterine space restriction causes dysregulation of the renin-angiotensin system in fetal kidneys. (Kranch-Shorthouse RA, Bauer AS, Magness RR, Lopez GE, Segar JL, Blohowiak SE, Kling PJ) Biol Reprod 2017 01 01;96(1):211-220 PMID: 28395333 PMCID: PMC6373835 04/11/2017    

• Renal adaptive changes and sodium handling in the fetal-to-newborn transition. (Segar JL) Semin Fetal Neonatal Med 2017 04;22(2):76-82 PMID: 27881286 11/25/2016  PlumX Metrics     2 Citations

• Increasing fetal ovine number per gestation alters fetal plasma clinical chemistry values. (Zywicki M, Blohowiak SE, Magness RR, Segar JL, Kling PJ) Physiol Rep 2016 08;4(16) PMID: 27565903 PMCID: PMC5002913 08/28/2016  PlumX Metrics     4 Citations

• Neonatal growth restriction-related leptin deficiency enhances leptin-triggered sympathetic activation and central angiotensin II receptor-dependent stress-evoked hypertension. (Peotta V, Rahmouni K, Segar JL, Morgan DA, Pitz KM, Rice OM, Roghair RD) Pediatr Res 2016 08;80(2):244-51 PMID: 27049292 PMCID: PMC4990468 04/07/2016  PlumX Metrics     2 Citations

• Maternal Hyperglycemia Directly and Rapidly Induces Cardiac Septal Overgrowth in Fetal Rats. (Gordon EE, Reinking BE, Hu S, Yao J, Kua KL, Younes AK, Wang C, Segar JL, Norris AW) J Diabetes Res 2015;2015:479565 PMID: 26064981 PMCID: PMC4439465 06/13/2015  PlumX Metrics     10 Citations

• ANG II modulation of cardiac growth and remodeling in immature fetal sheep. (Sandgren J, Scholz TD, Segar JL) Am J Physiol Regul Integr Comp Physiol 2015 Jun 01;308(11):R965-72 PMID: 25810382 PMCID: PMC4451391 03/27/2015  PlumX Metrics     5 Citations

• Hyperglycemia induces embryopathy, even in the absence of systemic maternal diabetes: an in vivo test of the fuel mediated teratogenesis hypothesis. (Baack ML, Wang C, Hu S, Segar JL, Norris AW) Reprod Toxicol 2014 Jul;46:129-36 PMID: 24721120 PMCID: PMC4067982 04/12/2014  PlumX Metrics     12 Citations

• Angiotensin II-induced cardiovascular load regulates cardiac remodeling and related gene expression in late-gestation fetal sheep. (Norris AW, Bahr TM, Scholz TD, Peterson ES, Volk KA, Segar JL) Pediatr Res 2014 Jun;75(6):689-696 PMID: 24614802 PMCID: PMC4251591 03/13/2014  PlumX Metrics     7 Citations

• Genotype-specific alterations in vascular smooth muscle cell function in cystic fibrosis piglets. (Guo JJ, Stoltz DA, Zhu V, Volk KA, Segar JL, McCray PB Jr, Roghair RD) J Cyst Fibros 2014 May;13(3):251-9 PMID: 24183914 PMCID: PMC3972271 11/05/2013  PlumX Metrics     11 Citations

• Urinary metabolomic markers of aminoglycoside nephrotoxicity in newborn rats. (Hanna MH, Segar JL, Teesch LM, Kasper DC, Schaefer FS, Brophy PD) Pediatr Res 2013 May;73(5):585-91 PMID: 23411940 PMCID: PMC3640567 02/16/2013  PlumX Metrics     25 Citations

• Thyroid hormone is required for growth adaptation to pressure load in the ovine fetal heart. (Segar JL, Volk KA, Lipman MH, Scholz TD) Exp Physiol 2013 Mar;98(3):722-33 PMID: 23104936 PMCID: PMC3578172 10/30/2012  PlumX Metrics  Article has an altmetric score of 1    15 Citations

• Impact of maternal dexamethasone on coronary PGE(2) production and prostaglandin-dependent coronary reactivity. (Roghair RD, Volk KA, Lamb FS, Segar JL) Am J Physiol Regul Integr Comp Physiol 2012 Sep 01;303(5):R513-9 PMID: 22832534 PMCID: PMC3468415 07/27/2012  PlumX Metrics     2 Citations

• Sex-specific programming of hypertension in offspring of late-gestation diabetic rats. (Katkhuda R, Peterson ES, Roghair RD, Norris AW, Scholz TD, Segar JL) Pediatr Res 2012 Oct;72(4):352-61 PMID: 22805998 PMCID: PMC3607358 07/19/2012  PlumX Metrics     24 Citations

• Maternal Hyperglycemia Disrupts Histone 3 Lysine 36 Trimethylation of the IGF-1 Gene. (Zinkhan EK, Fu Q, Wang Y, Yu X, Callaway CW, Segar JL, Scholz TD, McKnight RA, Joss-Moore L, Lane RH) J Nutr Metab 2012;2012:930364 PMID: 22548154 PMCID: PMC3324902 05/02/2012  PlumX Metrics  

• Neonatal diuretic therapy: furosemide, thiazides, and spironolactone. (Segar JL) Clin Perinatol 2012 Mar;39(1):209-20 PMID: 22341547 02/22/2012  PlumX Metrics     16 Citations

• Maternal antioxidant blocks programmed cardiovascular and behavioural stress responses in adult mice. (Roghair RD, Wemmie JA, Volk KA, Scholz TD, Lamb FS, Segar JL) Clin Sci (Lond) 2011 Nov;121(10):427-36 PMID: 21615331 PMCID: PMC3677964 05/28/2011  PlumX Metrics     17 Citations

• Programming of adult cardiovascular disease following exposure to late-gestation hyperglycemia. (Agoudemos M, Reinking BE, Koppenhafer SL, Segar JL, Scholz TD) Neonatology 2011;100(2):198-205 PMID: 21455011 PMCID: PMC3085032 04/02/2011  PlumX Metrics     11 Citations

• Transfusion effects on cardiomyocyte growth and proliferation in fetal sheep after chronic anemia. (Jonker SS, Scholz TD, Segar JL) Pediatr Res 2011 Jun;69(6):485-90 PMID: 21386752 PMCID: PMC3090539 03/10/2011  PlumX Metrics     8 Citations

• The effect of adrenalectomy on the cardiac response to subacute fetal anemia. (Jonker SS, Scholz TD, Segar JL) Can J Physiol Pharmacol 2011 Feb;89(2):79-88 PMID: 21326338 PMCID: PMC3097906 02/18/2011  PlumX Metrics     7 Citations

• Effect of insulin and dexamethasone on fetal assimilation of maternal glucose. (Norris AW, Wang C, Yao J, Walsh SA, Sawatzke AB, Hu S, Sunderland JJ, Segar JL, Ponto LL) Endocrinology 2011 Jan;152(1):255-62 PMID: 21084442 PMCID: PMC3219051 11/19/2010  PlumX Metrics     10 Citations

• Localized fetomaternal hyperglycemia: spatial and kinetic definition by positron emission tomography. (Yao J, Wang C, Walsh SA, Hu S, Sawatzke AB, Dang D, Segar JL, Ponto LL, Sunderland JJ, Norris AW) PLoS One 2010 Aug 06;5(8):e12027 PMID: 20700464 PMCID: PMC2917372 08/12/2010  PlumX Metrics     8 Citations

• Coronary endothelial function and vascular smooth muscle proliferation are programmed by early-gestation dexamethasone exposure in sheep. (Volk KA, Roghair RD, Jung F, Scholz TD, Lamb FS, Segar JL) Am J Physiol Regul Integr Comp Physiol 2010 Jun;298(6):R1607-14 PMID: 20335378 PMCID: PMC2886704 03/26/2010  PlumX Metrics     3 Citations

• Cardiomyopathy in offspring of diabetic rats is associated with activation of the MAPK and apoptotic pathways. (Reinking BE, Wedemeyer EW, Weiss RM, Segar JL, Scholz TD) Cardiovasc Diabetol 2009 Jul 31;8:43 PMID: 19646268 PMCID: PMC2731081 08/04/2009  PlumX Metrics     28 Citations

• Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats. (Segar EM, Norris AW, Yao JR, Hu S, Koppenhafer SL, Roghair RD, Segar JL, Scholz TD) Clin Sci (Lond) 2009 Jul 02;117(3):129-38 PMID: 19203348 PMCID: PMC2884292 02/11/2009  PlumX Metrics     28 Citations

• Vascular nitric oxide and superoxide anion contribute to sex-specific programmed cardiovascular physiology in mice. (Roghair RD, Segar JL, Volk KA, Chapleau MW, Dallas LM, Sorenson AR, Scholz TD, Lamb FS) Am J Physiol Regul Integr Comp Physiol 2009 Mar;296(3):R651-62 PMID: 19144750 PMCID: PMC2665850 01/16/2009  PlumX Metrics     32 Citations

• Fetal programming alters reactive oxygen species production in sheep cardiac mitochondria. (von Bergen NH, Koppenhafer SL, Spitz DR, Volk KA, Patel SS, Roghair RD, Lamb FS, Segar JL, Scholz TD) Clin Sci (Lond) 2009 Apr;116(8):659-68 PMID: 19032144 PMCID: PMC3677965 11/27/2008  PlumX Metrics     11 Citations

• Influence of early life events on health and diseases. (Robillard JE, Segar JL) Trans Am Clin Climatol Assoc 2006;117:313-9; discussion 319-20 PMID: 18528483 PMCID: PMC1500933 06/06/2008  PlumX Metrics     8 Citations

• Coronary constriction to angiotensin II is enhanced by endothelial superoxide production in sheep programmed by dexamethasone. (Roghair RD, Miller FJ Jr, Scholz TD, Lamb FS, Segar JL) Pediatr Res 2008 Apr;63(4):370-4 PMID: 18356741 PMCID: PMC3663587 03/22/2008  PlumX Metrics     7 Citations

• Activation of the mitogen-activated protein kinases and Akt in response to pulmonary artery banding in the fetal sheep heart is developmentally regulated. (Olson AK, Protheroe KN, Scholz TD, Segar JL) Neonatology 2008;93(3):145-52 PMID: 17878740 09/20/2007  PlumX Metrics     5 Citations

• Murine aortic reactivity is programmed equally by maternal low protein diet or late gestation dexamethasone. (Roghair RD, Segar JL, Kilpatrick RA, Segar EM, Scholz TD, Lamb FS) J Matern Fetal Neonatal Med 2007 Nov;20(11):833-41 PMID: 17853187 09/14/2007  PlumX Metrics     12 Citations

• Endothelial superoxide production is altered in sheep programmed by early gestation dexamethasone exposure. (Roghair RD, Miller FJ Jr, Scholz TD, Lamb FS, Segar JL) Neonatology 2008;93(1):19-27 PMID: 17630494 07/17/2007  PlumX Metrics     18 Citations

• Increased erythropoietin elimination in fetal sheep following chronic phlebotomy. (Freise KJ, Widness JA, Segar JL, Schmidt RL, Veng-Pedersen P) Pharm Res 2007 Sep;24(9):1653-9 PMID: 17457660 PMCID: PMC2863314 04/26/2007  PlumX Metrics     5 Citations

• Early gestation dexamethasone alters baroreflex and vascular responses in newborn lambs before hypertension. (Segar JL, Roghair RD, Segar EM, Bailey MC, Scholz TD, Lamb FS) Am J Physiol Regul Integr Comp Physiol 2006 Aug;291(2):R481-8 PMID: 16914435 08/18/2006  PlumX Metrics     28 Citations

• The mitogen-activated protein kinases and Akt are developmentally regulated in the chronically anemic fetal sheep heart. (Olson AK, Protheroe KN, Scholz TD, Segar JL) J Soc Gynecol Investig 2006 Apr;13(3):157-65 PMID: 16638585 04/28/2006  PlumX Metrics     11 Citations

• Mitogen-activated protein kinase activation and regulation in the pressure-loaded fetal ovine heart. (Olson AK, Protheroe KN, Segar JL, Scholz TD) Am J Physiol Heart Circ Physiol 2006 Apr;290(4):H1587-95 PMID: 16299265 11/22/2005  PlumX Metrics     15 Citations

• Regulation of myocardial glucose transporters GLUT1 and GLUT4 in chronically anemic fetal lambs. (Ralphe JC, Nau PN, Mascio CE, Segar JL, Scholz TD) Pediatr Res 2005 Oct;58(4):713-8 PMID: 16189198 09/29/2005  PlumX Metrics     13 Citations

• Myocardial vascular and metabolic adaptations in chronically anemic fetal sheep. (Mascio CE, Olison AK, Ralphe JC, Tomanek RJ, Scholz TD, Segar JL) Am J Physiol Regul Integr Comp Physiol 2005 Dec;289(6):R1736-45 PMID: 16123231 08/27/2005  PlumX Metrics     22 Citations

• Newborn lamb coronary artery reactivity is programmed by early gestation dexamethasone before the onset of systemic hypertension. (Roghair RD, Segar JL, Sharma RV, Zimmerman MC, Jagadeesha DK, Segar EM, Scholz TD, Lamb FS) Am J Physiol Regul Integr Comp Physiol 2005 Oct;289(4):R1169-76 PMID: 15961529 PMCID: PMC2730218 06/18/2005  PlumX Metrics     27 Citations

• Correlation between myocardial malate/aspartate shuttle activity and EAAT1 protein expression in hyper- and hypothyroidism. (Ralphe JC, Bedell K, Segar JL, Scholz TD) Am J Physiol Heart Circ Physiol 2005 May;288(5):H2521-6 PMID: 15615843 12/24/2004  PlumX Metrics     18 Citations

• Ontogeny of vascular growth factors in perinatal sheep myocardium. (van Natta TL, Ralphe JC, Mascio CE, Bedell KA, Scholz TD, Segar JL) J Soc Gynecol Investig 2004 Dec;11(8):503-10 PMID: 15582494 12/08/2004  PlumX Metrics     3 Citations

• Effects of cortisol on cardiac myocytes and on expression of cardiac genes in fetal sheep. (Lumbers ER, Boyce AC, Joulianos G, Kumarasamy V, Barner E, Segar JL, Burrell JH) Am J Physiol Regul Integr Comp Physiol 2005 Mar;288(3):R567-74 PMID: 15576665 12/04/2004  PlumX Metrics     57 Citations

• Apoptosis-related mitochondrial dysfunction in the early postoperative neonatal lamb heart. (Caldarone CA, Barner EW, Wang L, Karimi M, Mascio CE, Hammel JM, Segar JL, Du C, Scholz TD) Ann Thorac Surg 2004 Sep;78(3):948-55 PMID: 15337026 09/01/2004  PlumX Metrics     21 Citations

• Localization and function of the brain excitatory amino acid transporter type 1 in cardiac mitochondria. (Ralphe JC, Segar JL, Schutte BC, Scholz TD) J Mol Cell Cardiol 2004 Jul;37(1):33-41 PMID: 15242733 07/10/2004  PlumX Metrics  Article has an altmetric score of 3    24 Citations

• Early gestation dexamethasone programs enhanced postnatal ovine coronary artery vascular reactivity. (Roghair RD, Lamb FS, Miller FJ Jr, Scholz TD, Segar JL) Am J Physiol Regul Integr Comp Physiol 2005 Jan;288(1):R46-53 PMID: 15217789 06/26/2004  PlumX Metrics     30 Citations

• Neonatal vulnerability to ischemia and reperfusion: Cardioplegic arrest causes greater myocardial apoptosis in neonatal lambs than in mature lambs. (Karimi M, Wang LX, Hammel JM, Mascio CE, Abdulhamid M, Barner EW, Scholz TD, Segar JL, Li WG, Niles SD, Caldarone CA) J Thorac Cardiovasc Surg 2004 Feb;127(2):490-7 PMID: 14762359 02/06/2004  PlumX Metrics     34 Citations

• Late-gestation betamethasone enhances coronary artery responsiveness to angiotensin II in fetal sheep. (Roghair RD, Lamb FS, Bedell KA, Smith OM, Scholz TD, Segar JL) Am J Physiol Regul Integr Comp Physiol 2004 Jan;286(1):R80-8 PMID: 14512274 09/27/2003  PlumX Metrics     18 Citations

• Myocardial apoptosis after cardioplegic arrest in the neonatal lamb. (Hammel JM, Caldarone CA, Van Natta TL, Wang LX, Welke KF, Li W, Niles S, Barner E, Scholz TD, Behrendt DM, Segar JL) J Thorac Cardiovasc Surg 2003 Jun;125(6):1268-75 PMID: 12830043 06/28/2003  PlumX Metrics     14 Citations

• Inhibition of sympathetic responses at birth in sheep by lesion of the paraventricular nucleus. (Segar JL, Ellsbury DL, Smith OM) Am J Physiol Regul Integr Comp Physiol 2002 Dec;283(6):R1395-403 PMID: 12388455 10/22/2002  PlumX Metrics     12 Citations

• Metabolic adaptation of the fetal and postnatal ovine heart: regulatory role of hypoxia-inducible factors and nuclear respiratory factor-1. (Nau PN, Van Natta T, Ralphe JC, Teneyck CJ, Bedell KA, Caldarone CA, Segar JL, Scholz TD) Pediatr Res 2002 Aug;52(2):269-78 PMID: 12149506 08/01/2002  PlumX Metrics     31 Citations

• Effects of fetal ovine adrenalectomy on sympathetic and baroreflex responses at birth. (Segar JL, Van Natta T, Smith OJ) Am J Physiol Regul Integr Comp Physiol 2002 Aug;283(2):R460-7 PMID: 12121859 07/18/2002  PlumX Metrics     12 Citations

• Optimization of high-frequency oscillatory ventilation for the treatment of experimental pneumothorax. (Ellsbury DL, Klein JM, Segar JL) Crit Care Med 2002 May;30(5):1131-5 PMID: 12006814 05/15/2002  PlumX Metrics     18 Citations

• Effects of gestational age on myocardial blood flow and coronary flow reserve in pressure-loaded ovine fetal hearts. (Dalshaug GB, Scholz TD, Smith OM, Bedell KA, Caldarone CA, Segar JL) Am J Physiol Heart Circ Physiol 2002 Apr;282(4):H1359-69 PMID: 11893572 03/15/2002  PlumX Metrics     15 Citations

• Angiotensin II in cardiac pressure-overload hypertrophy in fetal sheep. (Segar JL, Dalshaug GB, Bedell KA, Smith OM, Scholz TD) Am J Physiol Regul Integr Comp Physiol 2001 Dec;281(6):R2037-47 PMID: 11705791 11/14/2001  PlumX Metrics     26 Citations

• Responses of fetal ovine systemic and umbilical arteries to angiotensin II. (Segar JL, Barna TJ, Acarregui MJ, Lamb FS) Pediatr Res 2001 Jun;49(6):826-33 PMID: 11385145 06/01/2001  PlumX Metrics     14 Citations

• Glucocorticoid modulation of cardiovascular and autonomic function in preterm lambs: role of ANG II. (Segar JL, Bedell KA, Smith OJ) Am J Physiol Regul Integr Comp Physiol 2001 Mar;280(3):R646-54 PMID: 11171641 02/15/2001  PlumX Metrics     28 Citations

• Autonomic adjustments to severe hypotension in fetal and neonatal sheep. (Nuyt AM, Segar JL, Holley AT, Robillard JE) Pediatr Res 2001 Jan;49(1):56-62 PMID: 11134492 01/03/2001  PlumX Metrics     7 Citations

• Metabolic adaptation of the hypertrophied heart: role of the malate/aspartate and alpha-glycerophosphate shuttles. (Rupert BE, Segar JL, Schutte BC, Scholz TD) J Mol Cell Cardiol 2000 Dec;32(12):2287-97 PMID: 11113004 12/13/2000  PlumX Metrics     29 Citations

• Sympathetic responses to cardiopulmonary vagal afferent stimulation during development. (Merrill DC, Segar JL, McWeeny OJ, Robillard JE) Am J Physiol 1999 10;277(4):H1311-6 PMID: 10516165 10/12/1999  PlumX Metrics     13 Citations

• Mechano- and chemoreceptor modulation of renal sympathetic nerve activity at birth in fetal sheep. (Segar JL, Smith OJ, Holley AT) Am J Physiol 1999 05;276(5):R1295-301 PMID: 10233019 05/08/1999  PlumX Metrics     5 Citations

• Development of baroreflex influences on heart rate variability in preterm infants. (Mazursky JE, Birkett CL, Bedell KA, Ben-Haim SA, Segar JL) Early Hum Dev 1998 Nov;53(1):37-52 PMID: 10193925 04/08/1999  PlumX Metrics     37 Citations
  Reply (George TN, Segar JL) J Pediatr 1999 Mar;134(3):383-4 PMID: 10064690 03/11/1999    

• Ontogeny and regulation of cardiac angiotensin types 1 and 2 receptors during fetal life in sheep. (Samyn ME, Petershack JA, Bedell KA, Mathews MS, Segar JL) Pediatr Res 1998 Sep;44(3):323-9 PMID: 9727708 09/04/1998  PlumX Metrics     21 Citations

• The effect of inhaled nitric oxide therapy on bleeding time and platelet aggregation in neonates. (George TN, Johnson KJ, Bates JN, Segar JL) J Pediatr 1998 Apr;132(4):731-4 PMID: 9580780 05/15/1998  PlumX Metrics     75 Citations

• Effect of antenatal glucocorticoids on sympathetic nerve activity at birth in preterm sheep. (Segar JL, Lumbers ER, Nuyt AM, Smith OJ, Robillard JE) Am J Physiol 1998 01;274(1):R160-7 PMID: 9458913 02/12/1998  PlumX Metrics     53 Citations

• Angiotensin AT1 receptor blockade fails to attenuate pressure-overload cardiac hypertrophy in fetal sheep. (Segar JL, Scholz TD, Bedell KA, Smith OM, Huss DJ, Guillery EN) Am J Physiol 1997 10;273(4):R1501-8 PMID: 9362317 11/15/1997  PlumX Metrics     36 Citations

• Ontogeny of the arterial and cardiopulmonary baroreflex during fetal and postnatal life. (Segar JL) Am J Physiol 1997 Aug;273(2 Pt 2):R457-71 PMID: 9277527 08/01/1997  PlumX Metrics     62 Citations

• Role of endogenous ANG II and AT1 receptors in regulating arterial baroreflex responses in newborn lambs. (Segar JL, Minnick A, Nuyt AM, Robillard JE) Am J Physiol 1997 Jun;272(6 Pt 2):R1862-73 PMID: 9227601 06/01/1997  PlumX Metrics     23 Citations

• Changes in body water compartments with diuretic therapy in infants with chronic lung disease. (Segar JL, Chemtob S, Bell EF) Early Hum Dev 1997 Apr 25;48(1-2):99-107 PMID: 9131311 04/25/1997  PlumX Metrics     9 Citations

• Arginine vasopressin modulation of arterial baroreflex responses in fetal and newborn sheep. (Nuyt AM, Segar JL, Holley AT, O'Mara MS, Chapleau MW, Robillard JE) Am J Physiol 1996 Dec;271(6 Pt 2):R1643-53 PMID: 8997365 12/01/1996  PlumX Metrics     16 Citations

• Regulation of renal sympathetic nerve activity at birth. (Mazursky JE, Segar JL, Nuyt AM, Smith BA, Robillard JE) Am J Physiol 1996 Jan;270(1 Pt 2):R86-93 PMID: 8769788 01/01/1996  PlumX Metrics     16 Citations

• Differential gene expression and regulation of renal angiotensin II receptor subtypes (AT1 and AT2) during fetal life in sheep. (Robillard JE, Page WV, Mathews MS, Schutte BC, Nuyt AM, Segar JL) Pediatr Res 1995 Dec;38(6):896-904 PMID: 8618791 12/01/1995  PlumX Metrics     45 Citations

• Effect of cortisol on gene expression of the renin-angiotensin system in fetal sheep. (Segar JL, Bedell K, Page WV, Mazursky JE, Nuyt AM, Robillard JE) Pediatr Res 1995 Jun;37(6):741-6 PMID: 7651758 06/01/1995  PlumX Metrics     61 Citations

• Impairment of cardiopulmonary baroreflexes during the newborn period. (Merrill DC, McWeeny OJ, Segar JL, Robillard JE) Am J Physiol 1995 Mar;268(3 Pt 2):H1343-51 PMID: 7900887 03/01/1995  PlumX Metrics     11 Citations

• Ontogenic changes and regulation of renal angiotensin II type 1 receptor gene expression during fetal and newborn life. (Robillard JE, Schutte BC, Page WV, Fedderson JA, Porter CC, Segar JL) Pediatr Res 1994 Dec;36(6):755-62 PMID: 7898984 12/01/1994  PlumX Metrics     44 Citations

• Changes in ovine renal sympathetic nerve activity and baroreflex function at birth. (Segar JL, Mazursky JE, Robillard JE) Am J Physiol 1994 Nov;267(5 Pt 2):H1824-32 PMID: 7977812 11/01/1994  PlumX Metrics     42 Citations

• Ontogenic changes in renal response to alpha 1-adrenoceptor stimulation in sheep. (Guillery EN, Segar JL, Merrill DC, Nakamura KT, Jose PA, Robillard JE) Am J Physiol 1994 Oct;267(4 Pt 2):R990-8 PMID: 7943440 10/01/1994  PlumX Metrics     9 Citations

• Cardiopulmonary and arterial baroreflex responses to acute volume expansion during fetal and postnatal development. (Merrill DC, Segar JL, McWeeny OJ, Smith BA, Robillard JE) Am J Physiol 1994 Oct;267(4 Pt 2):H1467-75 PMID: 7943393 10/01/1994  PlumX Metrics     7 Citations

• Role of sympathetic activity in the generation of heart rate and arterial pressure variability in fetal sheep. (Segar JL, Merrill DC, Smith BA, Robillard JE) Pediatr Res 1994 Feb;35(2):250-4 PMID: 8165062 02/01/1994  PlumX Metrics     20 Citations

• Role of endogenous ANG II on resetting arterial baroreflex during development. (Segar JL, Merrill DC, Robillard JE) Am J Physiol 1994 Jan;266(1 Pt 2):H52-9 PMID: 8304523 01/01/1994  PlumX Metrics     31 Citations

• Influence of renal nerves on renal function during development. (Robillard JE, Guillery EN, Segar JL, Merrill DC, Jose PA) Pediatr Nephrol 1993 Oct;7(5):667-71 PMID: 8251342 10/01/1993       14 Citations

• Hemodynamic changes during endotracheal suctioning are mediated by increased autonomic activity. (Segar JL, Merrill DC, Chapleau MW, Robillard JE) Pediatr Res 1993 Jun;33(6):649-52 PMID: 8378127 06/01/1993  PlumX Metrics     19 Citations

• Indomethacin compromises hemodynamics during positive-pressure ventilation, independently of prostanoids. (Malcolm DD, Segar JL, Robillard JE, Chemtob S) J Appl Physiol (1985) 1993 Apr;74(4):1672-8 PMID: 8514682 04/01/1993  PlumX Metrics     37 Citations

• Ontogeny of baroreflex control of renal sympathetic nerve activity and heart rate. (Segar JL, Hajduczok G, Smith BA, Merrill DC, Robillard JE) Am J Physiol 1992 Dec;263(6 Pt 2):H1819-26 PMID: 1481906 12/01/1992  PlumX Metrics     54 Citations

• Ontogeny of renal response to specific dopamine DA1-receptor stimulation in sheep. (Segar JL, Smith FG, Guillery EN, Jose PA, Robillard JE) Am J Physiol 1992 Oct;263(4 Pt 2):R868-73 PMID: 1357989 10/01/1992  PlumX Metrics     12 Citations

• Addition of metolazone to overcome tolerance to furosemide in infants with bronchopulmonary dysplasia. (Segar JL, Robillard JE, Johnson KJ, Bell EF, Chemtob S) J Pediatr 1992 Jun;120(6):966-73 PMID: 1593359 06/01/1992  PlumX Metrics     22 Citations

• Regulation of sodium metabolism and extracellular fluid volume during development. (Robillard JE, Segar JL, Smith FG, Jose PA) Clin Perinatol 1992 Mar;19(1):15-31 PMID: 1533579 03/01/1992  PlumX Metrics     16 Citations

• Mechanisms regulating renal sodium excretion during development. (Robillard JE, Smith FG, Segar JL, Guillery EN, Jose PA) Pediatr Nephrol 1992 Mar;6(2):205-13 PMID: 1533309 03/01/1992       39 Citations

• Renal nerves modulate kidney renin gene expression during the transition from fetal to newborn life. (Page WV, Perlman S, Smith FG, Segar JL, Robillard JE) Am J Physiol 1992 Mar;262(3 Pt 2):R459-63 PMID: 1373041 03/01/1992  PlumX Metrics     34 Citations

• Endocrine effects of ventilation, oxygenation and cord occlusion in near-term fetal sheep. (Smith FG, Smith BA, Segar JL, Robillard JE) J Dev Physiol 1991 Mar;15(3):133-8 PMID: 1834728 03/01/1991  PlumX Metrics     12 Citations