Duffy-Null Associated Neutrophil Count

Duffy-Null Associated Neutrophil Count

Neutrophils are a type of white blood cell that helps the body fight infection. Duffy-Null Associated Neutrophil Count (DANC) is a neutrophil count that is lower than the normal range for most people. Learn more what causes this and how it is diagnosed.
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What are Neutrophils?

Neutrophils are a type of white blood cell.  They help the body fight infection.

What is Duffy-Null Associated Neutrophil Count (DANC)?

This is a neutrophil count that is lower than the normal range for most people.

What Causes Duffy Null Associated Neutrophil Count?

  • It is caused by a change in the ACKR1 gene.  This is also called the Duffy gene.
  • It is very common in people with African or Middle Eastern ancestry.  More than half of people in the US from these backgrounds have DANC.

How is DANC Diagnosed?

Tests are done to:

  • measure the number of neutrophils in the blood. This is a blood test called a complete blood count.
  • confirm Duffy-null blood type. This is blood typing.
  • look for the change in the ACKR1 gene. This is genetic testing.

Are There Any Symptoms or Risk?

  • There are no symptoms of DANC.
  • People with DANC do not have a higher risk of infections. The lower neutrophil level is normal for people with the ACKR1 gene.

Is There Any Treatment Needed?

  • DANC is not a disease. No treatment is needed.
  • You will want to tell other doctors that you have DANC so they know why your neutrophil count is low.

ALERT

Call your child’s provider, nurse, or clinic if you have any questions or concerns or if your child has special health care needs that were not covered by this information.

Draft Number: 1802Revision Date: July 14, 2026

This content was created to help you care for your child and/or family member. It does not take the place of medical care. Talk with your healthcare provider for diagnosis, treatment and follow-up.