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Aoy Tomita-Mitchell

Aoy Tomita-Mitchell, PhD

Children’s Wisconsin since 2006
  • Investigator, Children's Research Institute
  • Professor, Pediatric Surgery, Medical College of Wisconsin

Locations

Overview

Division

  • Cardiothoracic Surgery

Research interests

  • Cell and developmental biology
  • Fetal concerns/prematurity diseases
  • Genetic diseases/genomics
  • Heart disease
  • Congenital heart disease
  • Solid organ transplantation

Study interests

  • Development and utilization of high-throughput methodologies for identifying inherited risk factors
  • Genetic and molecular etiology of congenital heart disease
  • Mutation detection technologies

Education

  • Doctorate, Massachusetts Institute of Technology, Cambridge, 2000; postdoctoral fellow, Massachusetts Institute of Technology, Cambridge, 2000
  • Postdoctoral fellow, Pediatric Cardiology, The Children's Hospital of Philadelphia, 2004

Areas of Interest

  • Research faculty
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Education and Awards

Education

Awards

  • Wisconsin Inno's "50 on Fire," 2018
  • USA Olympic Intercollegiate Engineering Design competition, first place, Denver, 1993
  • Ida Green Fellow, Massachusetts Institute of Technology, Cambridge, 1994
  • Poitras Biomedical Engineering/Biophysics Fellow, Massachusetts Institute of Technology, Cambridge, 1998
  • Aspen Cancer Conference Fellow, Colo., 1999
  • The Business Journal's "Forty under 40," 2009

Research and publications

Research

  • Lymphoproliferative Disorders in Primary Immunodeficiencies, National Institutes of Health (NIH)/National Cancer Institute (NCI), co-investigator (5%), 1/11/11 - 12/31/12
  • Inflammation and Infection in Acquired and Congenital Cardiovascular Disease, role, key/senior personnel and mentor, 2/1/09 - 1/31/14
  • Formative Project within the Pilot Phase of the NCS, The National Children's Study - Vanguard Center; role, lead site investigator, Waukesha County Vanguard Site, MCW subaward, 4/1/11 - 3/31/12



Publications

Deshpande SR, Zangwill SD, Richmond ME, Kindel SJ, Schroder JN, Gaglianello N, Bichell DP, Wigger MA, Knecht KR, Thrush PT, Mahle WT, North PE, Simpson PM, Zhang L, Dasgupta M, Tomita-Mitchell A, Mitchell ME.  Evaluating threshold for donor fraction cell-free DNA using clinically available assay for rejection in pediatric and adult heart transplantation.  Pediatr Transplant.   2024 May;28(3):e14708 PMID: 38553812 PMCID: PMC10987078 SCOPUS ID: 2-s2.0-85189497658 03/30/2024

Wolfe JT, He W, Kim MS, Liang HL, Shradhanjali A, Jurkiewicz H, Freudinger BP, Greene AS, LaDisa JF Jr, Tayebi L, Mitchell ME, Tomita-Mitchell A, Tefft BJ.  3D-bioprinting of patient-derived cardiac tissue models for studying congenital heart disease.  Front Cardiovasc Med.   2023;10:1162731 PMID: 37293290 PMCID: PMC10247285 SCOPUS ID: 2-s2.0-85161445064 06/09/2023

Thareja SK, Anfinson M, Cavanaugh M, Kim MS, Lamberton P, Radandt J, Brown R, Liang HL, Stamm K, Afzal MZ, Strande J, Frommelt MA, Lough JW, Fitts RH, Mitchell ME, Tomita-Mitchell A.  Altered contractility, Ca2+ transients, and cell morphology seen in a patient-specific iPSC-CM model of Ebstein's anomaly with left ventricular noncompaction.  Am J Physiol Heart Circ Physiol.   2023 Jul 01;325(1):H149-H162 PMID: 37204873 PMCID: PMC10312315 SCOPUS ID: 2-s2.0-85164047409 05/19/2023

Tanem JM, Scott JP, Hoffman GM, Niebler RA, Tomita-Mitchell A, Stamm KD, Liang HL, North PE, Bertrandt RA, Woods RK, Hraska V, Mitchell ME.  Nuclear Cell-Free DNA Predicts Adverse Events After Pediatric Cardiothoracic Surgery.  Ann Thorac Surg.   2023 Aug;116(2):349-356 PMID: 36332680 SCOPUS ID: 2-s2.0-85150823960 11/05/2022

Richmond ME, Deshpande SR, Zangwill SD, Bichell DP, Kindel SJ, Mahle WT, Schroder JN, Wigger MA, Knecht KR, Pahl E, Gaglianello NA, Goetsch MA, Simpson P, Dasgupta M, Zhang L, North PE, Tomita-Mitchell A, Mitchell ME.  Validation of donor fraction cell-free DNA with biopsy-proven cardiac allograft rejection in children and adults.  J Thorac Cardiovasc Surg.   2023 Feb;165(2):460-468.e2 PMID: 35643770 PMCID: PMC9617812 SCOPUS ID: 2-s2.0-85130912386 06/02/2022

Anfinson M, Fitts RH, Lough JW, James JM, Simpson PM, Handler SS, Mitchell ME, Tomita-Mitchell A.  Significance of α-Myosin Heavy Chain (MYH6) Variants in Hypoplastic Left Heart Syndrome and Related Cardiovascular Diseases.  J Cardiovasc Dev Dis.   2022 May 03;9(5) PMID: 35621855 PMCID: PMC9147009 05/28/2022

Thareja SK, Frommelt MA, Lincoln J, Lough JW, Mitchell ME, Tomita-Mitchell A.  A Systematic Review of Ebstein's Anomaly with Left Ventricular Noncompaction.  J Cardiovasc Dev Dis.   2022 Apr 13;9(4) PMID: 35448091 PMCID: PMC9031964 SCOPUS ID: 2-s2.0-85129039352 04/22/2022

Deshpande SR, Zangwill SD, Kindel SJ, Schroder JN, Bichell DP, Wigger MA, Richmond ME, Knecht KR, Pahl E, Gaglianello NA, Mahle WT, Stamm KD, Simpson PM, Dasgupta M, Zhang L, North PE, Tomita-Mitchell A, Mitchell ME.  Relationship between donor fraction cell-free DNA and clinical rejection in heart transplantation.  Pediatr Transplant.   2022 Jun;26(4):e14264 PMID: 35258162 SCOPUS ID: 2-s2.0-85125904987 03/09/2022

Scott JP, Tanem JM, Tomita-Mitchell A, Hoffman GM, Niebler RA, Liang HL, Simpson PM, Stamm KD, North PE, Mitchell ME.  Elevated nuclear and mitochondrial cell-free deoxyribonucleic acid measurements are associated with death after infant cardiac surgery.  J Thorac Cardiovasc Surg.   2022 Aug;164(2):367-375 PMID: 35144816 SCOPUS ID: 2-s2.0-85120861361 02/12/2022

Zangwill SD, Deshpande SR, Simpson PM, Liang HL, Zhang L, Dasgupta M, Richmond ME, Kindel SJ, Bichell DP, Mahle WT, Wigger MA, Schroder JN, Knecht KR, Pahl E, Gaglianello NA, North PE, Tomita-Mitchell A, Mitchell ME.  Increase in nuclear cell-free DNA is associated with major adverse events in adult and pediatric heart transplant recipients.  Clin Transplant.   2022 Jan;36(1):e14509 PMID: 34649304 SCOPUS ID: 2-s2.0-85120575732 10/15/2021


Publications of Aoy Tomita Mitchell PhD from the Faculty Collaboration Database

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