Clinical trials

The Gastroenterology, Liver and Nutrition Program at Children's Wisconsin is dedicated to furthering research that could lead to better treatments for kids. You can help.

Not only does we see patients from around the world, but we're also dedicated to advancing research aimed at improving treatments and outcomes in children with chronic disease. 

There’s still much we don’t know about the complex GI problems that can affect children. That’s why Children’s Wisconsin invites patients and their families to participate in important clinical trials led by our own researchers and our partners at leading pediatric programs around the nation. These studies give our patients access to cutting-edge new treatments while yielding important insights into what causes these conditions in the first place.

Safety is our top priority, and our Institutional Review Board carefully reviews every clinical study.

• Overview of infection, inflammation and immunity research at Children’s Research Institute 
• Why pediatric research matters 

Recent clinical trials have included:

• A Phase 2/3 Randomized, Double-Blind Study of Oral Ozanimod in Pediatric Subjects with Moderate to Severe Active Ulcerative Colitis
• Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed with Crohn’s Disease
• Precise Infliximab Exposure and Pharmacodynamic Control to Achieve Remission in Pediatric Crohn’s Disease 
• A Phase III Study to Assess the Efficacy and Safety of NEXIUM for Maintenance of Healing of Erosive Esophagitis in Pediatric Patients 
• Autonomic Reactivity to Restore a Dysregulated Brain-Gut Axis

Want to get involved? Find a list of all the current studies at Children’s Research Institute or learn more about research at Children’s Wisconsin:

Current research

In collaboration with the Medical College of Wisconsin, Children’s Wisconsin’s Inflammatory Bowel Disease Program team continues to get involved in national and regional research studies. This allows patients to get involved in advancing science and improving our understanding of the disease, and helping develop new treatment options. Some examples of our research are: 

• National registries – This can range from answering questionnaires, to blood or tissue samples, or helping track disease activity across the country. 
• Genetics and tissue banking – Collecting blood or tissue to determine how the disease is passed through families and if there are changes over time. 
• Microbiome – Stool collection to find a connection between what is in the stool and the disease activity. 
• Drug and treatment trials – This ranges from testing the effectiveness and safety of relatively new medications to continuing to survey well-established medications. 
• Immunological testing – Looking for patterns of abnormal immune system function among patients with IBD.