In this section
Blood and marrow transplant
Children's is a pioneer in pediatric blood marrow transplant. We performed our first bone marrow transplant in 1980 and have since then completed more than 1,000 successful transplants.
Few hospitals are as equipped as Children's to provide the most advanced care and expertise in blood and marrow transplant. We have a family-centered approach and partner with you and your family through every step of the process, providing the support, guidance and information you need.
Types of BMT
Bone marrow transplantation takes cells from a donor's bone marrow (stem cells), filters those cells, and gives them back either to the patient they were taken from or to another person. This replaces the unhealthy bone marrow in a sick child.
There are three main types of BMT:
- Autologous – Your child's stem cells are harvested, treated and returned to the body healthy.
- Allogeneic – A donor with the same genetic type as your child donates stem cells. It usually is a brother or sister but can be from a parent or even an unrelated donor.
- Umbilical cord blood transplant – Stem cells are removed from an umbilical cord immediately after a baby is delivered. They are then transplanted into your child.
Our BMT team
Our team works closely with you from day one to coordinate all aspects of your child's care and treatment – from the initial phone call to post transplant and outpatient transition. We always are available to answer any questions you may have.
Our team includes specialists from:
- Pediatric oncology and hematology
- Infectious disease
- Radiation oncology
Patients and families also receive support from social workers, child life specialists, child psychologists and a BMT coordinator.
There are a number of childhood disorders and cancers for which blood and marrow transplant might be the best course of treatment. These include:
- Hemophagocytic lymphohistiocytosis (HLH)
- Primary immunodeficiencies
- Severe aplastic anemia
- Sickle cell anemia
- Metabolic storage diseases
Learn more about the BMT conditions >>
The BMT transplant process at Children's involves the following steps:
- Meet with the blood and marrow transplant team
- Finding a donor
- Pre-transplant education
- Blood and marrow transplant
- Follow up
Learn more about the BMT process >>
Our ongoing commitment to improving the BMT process includes involvement in research to work towards better outcomes every day. This includes active participation in clinical trials and research.
Meet Dr. Margolis and learn about pediatric blood and marrow transplant.