Blood and Marrow Transplant Conditions

At Children's, our outstanding team specializes in treating a wide range of diseases that can require a blood and marrow transplant.


Leukemia – the most common of all childhood cancer – is cancer of the white blood cells in the bone marrow. Bone marrow is the spongy center inside the long bones of your child's body. These unhealthy white cells grow and spread, beginning to take over the healthy white blood cells. There are three main types of childhood leukemia: acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML) and chronic myeloid leukemia (CML).

Learn more >>

Leukemia care at Children's

In most cases, leukemia is treatable. Treatment depends on a number of factors, including the type of leukemia, your child's age, overall health and medical history. At Children's, we work to alleviate symptoms first, then move on to other treatment methods, which may include chemotherapy, radiation and/or bone marrow transplantation.

Learn more >>


Lymphomas are cancers of the lymphatic system, which fights disease and infections in your child's body. They are classified as either non-Hodgkin's or, more rarely, Hodgkin's, depending on the type of white blood cells involved.

Lymphoma care at Children's

Treatment depends on the type of lymphoma. It may include chemotherapy, radiation, surgery, antiviral medications, chemotherapy, immunotherapy and bone marrow transplantation.

Hemophagocytic Lymphohistiocytosis (HLH)

HLH is a rare but serious condition that is most often seen in infants and children. With HLH, certain white blood cells build up in your child's organs and destroy other, healthy blood cells. As a result, your child may experience fever, as well as damage and swelling of the liver and spleen.

Hemophagocytic lymphohistiocytosis care at Children's

There are a number of different treatment options for HLH, including antibiotics, antiviral medications, chemotherapy, immunotherapy and bone marrow transplantation.

Primary Immunodeficiencies

Primary immunodeficiencies are a number of disorders that threaten your child's immune system and make him or her more susceptible to infections. If left untreated, these infections may be fatal.

Learn more >> 

Primary immunodeficiencies care at Children's

At Children's, we treat primary immunodeficiencies with antibiotics, additional therapies, and sometimes bone marrow transplantation.

Severe Aplastic Anemia

Aplastic anemia occurs when your child's bone marrow does not produce enough blood cells. It leaves your child with not enough oxygen to the organs, susceptible to infection, and possible blood clotting disorders.

Learn more >>

Severe aplastic anemia care at Children's

Treatment varies and is based on a number of factors, including your child's age, medical history, and overall health as well as the extent and cause of severe aplastic anemia.

Sickle Cell Anemia

Sickle cell diseases are inherited disorders in which your child's red blood cells are not the normal shape. This makes it harder for the blood cells to travel through the veins and arteries, and blood and oxygen have trouble reaching your child's vital organs. As a result, your child may experience pain, infections, anemia, and damage to the organs.

Learn more >>

Sickle cell anemia care at Children's

Our team treats sickle cell anemia with a number of different protocols, including medicine (such as antibiotics and pain medication), as well as blood transfusions and, if indicated, bone marrow transplant.


Hemoglobin is a protein found in your body's red blood cells, which helps carry oxygen to the rest of the body. When your child has thalassemia, his or her body produces an abnormal form of hemoglobin. As a result, healthy red blood cells are destroyed, which leads to anemia.

Thalassemia care at Children's

Treatment for thalassemia may include regular blood transfusions and folate supplements. In addition, a bone marrow transplant may be indicated.

Metabolic Storage Diseases

There are a number of rare, inherited metabolic storage diseases we see and treat at Children's. All involve a defective type of protein that is built up in your child's system, causing symptoms ranging from seizures to enlarged liver or spleen to bones that don't grow normally.

Metabolic storage disease care at Children's

Treatment for metabolic storage diseases varies, depending on the type of disease and its severity. In addition to treating the symptoms, in some cases, a bone marrow transplant may be indicated.

Make an appointment

To make an appointment, call our Central Scheduling team or request an appointment online.

(877) 607-5280

Request an appointment

Haga clic aquí para ver esta página en español

Featured video


Meet Dr. Margolis and learn about pediatric blood and marrow transplant.