Next Steps survivorship program

Survivorship research

The Next Steps Team continues to provide the most current, evidence-based survivorship care for our patients. We are involved in national and international research groups, as well as our own local research efforts. The potential for long term complications, or late effects, after therapy is complete varies for each cancer survivor. Late effects can be physical, effecting the body's organ systems (like heart health or reproductive function), or psycho-social (like fear of recurrence), effecting quality of life. We are working to better understand the risk factors for late effects and learn more about how we can help prevent and treat them in the best way possible. Our research efforts have helped us coordinate care with other sub-specialties (or medical teams) for specialized care, develop Survivorship Care Plans to guide the best and safest care after cancer treatment is complete, and it has positioned us to better understand when supportive resources are needed. We continue to learn from our research to better serve our survivors for them to live happy and healthy lives.

If a full article is needed, please email the research team.

If you are interested in future research studies, please fill out our form

Open for enrollment

Title: Effects of Modern Chemotherapy Regimens on Spermatogenesis and Steroidogenesis in Adolescent and Young Adult (AYA) Survivors of Osteosarcoma

Local primary investigator: Rachel Phelan, MD

Purpose: This study is hoping to determine whether infertility and/or biomarkers of spermatogenesis and steroidogenesis differ in male osteosarcoma survivors treated with cisplatin with or without ifosfamide compared to male controls without a history of cancer. This study also hopes to evaluate whether cisplatin with or without ifosfamide for the treatment of osteosarcoma alters sperm DNA methylation.

Quality of life/outcomes

Becktell K, Simpson P, Phelan R, Schmidt D, Anderson L, Nichols J, & Bingen, K. Developmental differences in health-related quality of life in adolescent and young adult cancer survivors [published online ahead of print, 2020 Apr 22]. Qual Life Res. 2020;10.1007/s11136-020-02507-4. doi:10.1007/s11136-020-02507-4
Chan, S., Hoag, J.A., Karst, J., & Bingen, K. (2018, Nov.). Social adjustment of adolescent cancer patients transitioning off active treatment: A short-term longitudinal mixed methods study. Pediatr Blood & Cancer. DOI: 10.1002/pbc.27530.
Bingen, K., Schroedl, R.L., Anderson, L., Schmidt, D., Hoag, J., Christiansen, H., & Kupst, M.J. (2012, Jan). A multi-method assessment of psychosocial functioning and late effects in survivors of childhood cancer and hematopoietic cell transplant. J Pediatr Hematol Oncol, 34 (1), 22-28. DOI: 10.1097/MPH.0b013e3182281f8e.
Bingen, K., Anderson, L., Schmidt, D., Maloney, K., Margolis, D., Warwick, A., & Kupst, M. J. (2004, Jan). Psychosocial functioning of long-term survivors of childhood cancer [Abstract]. Psycho-Oncology, 13 (Suppl. 1), 56.

Fertility

Phelan R, Mann E, Napurski C, DeFor TE, Petryk A, Miller WP, Wagner JE, Verneris MR, Smith AR. Ovarian function after hematopoietic cell transplantation: a descriptive study following the use of GnRH agonists for myeloablative conditioning and observation only for reduced-intensity conditioning. Bone Marrow Transplant. 2016 Oct;51(10):1369-1375. PMCID: PMC5299542

Programmatic

Bingen, K., Hoag, J., Anderson, L., Chan, S., Gouthro, K.C., Nichols, J., Phelan, R., Schmidt, D., & Karst, J. (2019). Bridge to Next Steps: Evaluation of a transition to survivorship program [Abstract]. Journal of Psychosocial Research & Practice, 1(1S): e11.
Karst, J., Hoag, J., Chan, S., Schmidt, D., Anderson, L., Englebert, N., Igler, E., & Bingen, K. (2018, April). Assessment of end-of-treatment transition needs for pediatric cancer and hematopoietic stem cell transplant patients and their families. Pediatr Blood & Cancer.
Bingen, K., & Kupst, M.J. (2010, March). Evaluation of a survivorship educational program for adolescent and young adult survivors of childhood cancer. J Cancer Educ, 25(4), 530-37. DOI: 10.1007/s13187-010-0077-y.

Medical - BMT

Kahn JM, Brazauskas R, Tecca HR, Bo-Subait S, Buchbinder D, Battiwala M, Flowers MED, Savani BN, Phelan R, Broglie L, Abraham AA, Keating AK, Daly A, Wirk B, George B, Alter BP, Ustun C, Freytes CO, Beitinjaneh AM, Duncan C, Copelan E, Hildebrandt GC, Murthy HS, Lazarus HM, Auletta JJ, Myers KC, Williams KM, Page KM, Vrooman LM, Norkin M, Byrne M, Diaz MA, Kamani N, Bhatt NS, Rezvani A, Farhadfar N, Mehta PA, Hematti P, Shaw PJ, Kamble RT, Schears R, Olsson RF, Hayaski RJ, Gale RP, Mayo SJ, Schhabra S, Rotz SJ, Badawy SM, Ganguly S, Pavletic S, Nishihori T, Prestidge T, Agrawal V, Hogan WJ, Inamoto Y, Shaw BE, Satwani P. Subsequent neoplasms and late mortality in children undergoing allogeneic transplantation for nonmalignant diseases. Blood Adv. 2020 May 12;4(9):2084-2094.
Scheuermann A, Phelan R, Browning M. Development of Secondary Osteosarcoma After TBI and Allogeneic Bone Marrow Transplant: A Case Series of 3 Patients. J Pediatr Hematol Oncol. 2020 Mar;42(2):e100-e103
Lee CJ, Kim S, Tecca HR, Bo-Subait S, Phelan R, Brazauskas R, Buchbinder D, Hamilton BK, Battiwalla M, Majhail NS, Lazarus HM, Shaw PJ, Marks DI, Litzow MR, Chhabra S, Inamoto Y, DeFilipp Z, Hildebrandt GC, Olsson RF, Kasow KA, Liesveld JL, Rotz SJ, Badawy SM, Bhatt NS, Yared JA, Page KM, Arellano ML, Kent M, Farhadfar N, Seo S, Hematti P, Freytes CO, Rovó A, Ganguly S, Nathan S, Burns L, Shaw BE, Muffly LS. Late effects after ablative allogeneic stem cell transplantation for adolescent and young adult acute myeloid leukemia. Blood Adv. 2020 Mar 24;4(6):983-992. PMCID: PMC70940
Bhatt NS, Brazauskas R, Tecca HR, Carreras J, Burns LJ, Phelan R, Salit RB, Syrjala KL, Talano JM, Shaw BE. Post-transplantation employment status of adult survivors of childhood allogeneic hematopoietic cell transplant: A report from the Center for International Blood and Marrow Transplant Research (CIBMTR). Cancer. 2019 01 01;125(1):144-152. PMCID: PMC6310211
Pierpont EI, McCoy E, King KE, Ziegler RS, Shanley R, Nascene D, Raymond GV, Phelan R, Lund TC, Orchard PJ, Miller WP. Post-transplant adaptive function in childhood cerebral adrenoleukodystrophy. Ann Clin Transl Neurol. 2018 03;5(3):252-261. PMCID: PMC5846389
Anderson, L., Schmidt, D., Bingen, K., Kupst, M.J., & Warwick, A. (2009, Nov-Dec). Growth velocity in pediatric bone marrow transplantation: Significance of donor type and treatment factors, J Pediatr Oncol Nurs, 26 (6), 377-382. PMID: 20032299.

Medical - Oncology

Phelan R, Eissa H, Becktell K, Bhatt N, Kudek M, Nuechterlein B, Pommert L, Tanaka R, Baker KS. Upfront Therapies and Downstream Effects: Navigating Late Effects in Childhood Cancer Survivors in the Current Era. Curr Oncol Rep. 2019 Nov 25;21(12):104.
Schmidt, D., Anderson, L., Bingen, K., Cooper, J., Kupst, M.J., & Warwick, A. (2010, April). Late effects in adult survivors of childhood cancer: Considerations for the general practitioner. WMJ, 109 (2), 98-107.

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