Bone marrow failure

Bone Marrow Failure at Children’s Wisconsin

Bone marrow failure occurs when the bone marrow cannot produce enough blood cells. There are two primary types of bone marrow failure:

• Genetic (Inherited): Passed down through families, these rare disorders are associated with an increased risk of cancer.
• Acquired: Caused by external factors, such as viruses or toxins, these conditions include aplastic anemia, paroxysmal nocturnal hemoglobinuria, and certain neutropenias, which affect blood cell production.

Types of Bone Marrow Failure:

• Inherited Marrow Failure: Conditions passed from parents, often leading to higher cancer risks.
• Acquired Marrow Failure: Includes aplastic anemia (failure to produce blood cells), paroxysmal nocturnal hemoglobinuria (impaired blood cell production), and neutropenias (low white blood cells).

Treatment Approach:

Treatment varies based on the type of marrow failure and may include blood and marrow transplants or medical therapies. The expert team at Children's Wisconsin led by Drs. David Margolis and Larisa Broglie provides personalized care for each patient, with a focus on family guidance throughout the process.

Research Advancements:

Children's Wisconsin is exploring new therapies for marrow failure, including Treosulfan, a chemotherapy drug that offers fewer side effects and improved success rates for marrow transplants.

For more information or to schedule an appointment, call (414) 266-2420.