Immune deficiencies and immune dysregulation disorders

Immune deficiencies and immune dysregulation disorders are a broad category of nonmalignant (noncancerous) conditions treated at the MACC Fund Center for Cancer and Blood Disorders at Children’s Wisconsin. These disorders include:

  • Severe combined immunodeficiency, a group of rare diseases that cause a child to have very little or no immune system
  • Common variable immunodeficiency, a disorder that causes a low level of antibodies
  • DiGeorge syndrome, a chromosomal abnormality that can cause immune system problems
  • Histiocytosis, a group of disorders characterized by too many of a specific type of white blood cells called histiocytes

Why choose Children’s

More than a decade ago, Children’s Wisconsin was one of the first medical centers in the country to screen newborns for immune deficiencies and immune dysregulation disorders. When our team could diagnose these conditions within days of birth—rather than weeks or months—we standardized our operating procedures to manage the care of our youngest patients.

Today, our immune deficiencies and immune dysregulation disorders program, led by pediatric hematologist-oncologist Larisa Broglie, MD, remains a leader in the field. Our clinical care team partners with other Children’s Wisconsin expert providers, including those within our immunology center, rheumatology service, hematology department, infectious disease program, gastroenterology program, and genetics and genomics program. Bringing multiple specialties together as needed ensures comprehensive patient care.

Our team also works closely with national organizations focused on immune deficiencies and immune dysregulation disorders, such as the Primary Immune Deficiency Treatment Consortium and the North American Consortium for Histiocytosis.

At Children’s Wisconsin, our state-of-the-art Clinical Immunodiagnostic and Research Laboratory (CIRL) evaluates pediatric patients for primary immune deficiencies. The CIRL is a partnership with the Medical College of Wisconsin.  It also is recognized as a Jeffrey Modell Diagnostic Center for primary immune deficiencies.

For more information or to make an appointment, call (414) 266-2420.